Sofosbuvir as backbone of interferon free treatments

Interferon-Free Treatments for Chronic Hepatitis C Genotype 1 Infection

Hepatitis C virus (HCV) infection affects as many as 185 million people globally, many of whom are chronically infected and progress over time to cirrhosis, decompensated liver disease, hepatocellular carcinoma, and eventually death without a liver transplant. In the United States, HCV genotype 1 constitutes about 75% of all infections. While interferon and ribavirin therapy was the cornerstone...

Cost analysis of sofosbuvir/ribavirin versus sofosbuvir/simeprevir for genotype 1 hepatitis C virus in interferon-ineligible/intolerant individuals.

UNLABELLED Treatment guidance for chronic hepatitis C (CHC) released by the American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) offers two options for interferon (IFN)-ineligible/intolerant individuals with genotype 1 infection: sofosbuvir/ribavirin (SOF/RBV) for 24 weeks or sofosbuvir/simeprevir (SOF/SMV) for 12 weeks. A 24-week co...

NMR Backbone Assignments and Secondary Structure of Human Interferon-$

'H, 13C, and '5N NMR assignments of the protein backbone of human interferon-y, a homodimer of 3 1.4 kDa, have been made using the recently introduced three-dimensional (3D) triple-resonance NMR techniques, It is shown that, despite the -40-50-HZ 13Ca and *Ha line widths of this high molecular weight dimer and the extensive overlap in the 'Ha and I3Ca spectral regions, unique sequential assignm...

rational development of a polycistronic plasmid with a cpg-free bacterial backbone as a potential tool for direct reprogramming

objective: induced pluripotent stem cells are generated from somatic cells by direct reprogramming. these reprogrammed pluripotent cells have different applications in biomedical fields such as regenerative medicine. although viral vectors are widely used for efficient reprogramming, they have limited applications in the clinic due to the risk for immunogenicity and insertional mutagenesis. acc...

sofosbuvir vs. combination of pegylated interferon and ribavirin; how much shall pay for iranian patients?